Packaging Technology

Achema 2012 Bosch presents Fast Air Lock ISS 1000 for quick

and contamination-free transfer New development underlines leading position

  • Cycle times of only 20 minutes depending on load
  • Available as stand-alone and integrated version
  • 100th Bosch isolator sold to international pharma customer
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  • April 19, 2012
  • Packaging Technology
  • Press releases

press release

At Achema 2012 in Frankfurt/Main, Germany, Bosch Packaging Technology introduces the new Fast Air Lock ISS 1000 at its booth (C70, C72) in hall 3.1. The new machine was developed for the fast and contamination-free transfer of pharmaceutical equipment into and out of isolators. It operates independently from the status of the main filling isolator and can, for instance, transfer microbiological materials. With an especially efficient evaporation process and an optimized loading unit, cycle times of this new development have been significantly reduced. The external door of the lock can be opened while the isolator is in operation. Bio-decontamination can also occur independently from the operating condition of the main isolator. The transfer cart enables a very ergonomic loading and unloading of the lock. This leads to optimized loading patterns and consequently to minimized transfer times. Depending on the load, the ISS 1000 only needs approximately 20 minutes per cycle.

The new ISS 1000 is equipped with the well-proven bio-decontamination system Bosch SafeVAP, which ensures a safe evaporation of hydrogen peroxide. Air supply is generated from the ambient space while the exhaust air is conducted to the outside of the building. The air within the lock is conducted by Hepa filters.

The ISS 1000 is available as integrated or stand-alone version. The inner door of the integrated version opens directly into the main isolator to which it is firmly connected. Instead of the inner door, the stand-alone unit has an aseptic interface in the form of an RTP (rapid transfer port) system. In this version, the connected container and the lock are decontaminated simultaneously. Due to the independent container transfer, several filling lines can be supported with only one ISS 1000. The transfer container is loaded by means of a glove which is integrated into the door.

System competence for isolator technology
For more than 20 years, Bosch Packaging Technology has developed isolators for the pharmaceutical industry. Compared to conventional cleanroom production, isolators offer higher product quality, lower operating costs and a safe accomplishment of longer production cycles. Bosch isolator systems are available for all machine types processing ampoules, vials, cartridges and ready-to-use syringes.

Bosch underlines its pioneering position in the field of isolator technology with the current sale of its 100th isolator to an international pharmaceutical customer. At Achema, this isolator is showcased with an FLC filling and sealing machine and will be delivered to the customer after the trade fair. The FLC fills up to 24,000 vials and infusion bottles per hour and is available for cleanroom conditions and as isolator version. The isolator is the smallest, safest and most economical solution for a sterile room.

At the customer’s site, the isolator will be used in combination with an entire vial filling and sealing line for highly potent pharmaceuticals. The filling machine is connected upstream to a washing machine and a sterilization tunnel. The filled vials are loaded into a freeze dryer and transported to a capping machine after lyophilisation. The isolator ensures a sterile and contamination-free process from the end of the sterilization tunnel to the loading station of the freeze dryer and to the capping machine. Apart from product protection, the safety of the operating personnel is given top priority in the processing of highly potent agents.

Based in Waiblingen near Stuttgart, Germany, and employing 6,200 associates, the Bosch Packaging Technology division is one of the leading suppliers of process and packaging technology. At over 30 locations in more than 15 countries worldwide, a highly-qualified workforce develops and produces complete solutions for the pharmaceuticals, food, and confectionery industries. These solutions are complemented by a comprehensive after-sales service portfolio. A global service and sales network provides customers with local points of contact.

Additional information is available online at

The Bosch Group is a leading global supplier of technology and services. It employs roughly 375,000 associates worldwide (as of December 31, 2015). The company generated sales of 70.6 billion euros in 2015. Its operations are divided into four business sectors: Mobility Solutions, Industrial Technology, Consumer Goods, and Energy and Building Technology. The Bosch Group comprises Robert Bosch GmbH and its roughly 440 subsidiaries and regional companies in some 60 countries. Including sales and service partners, Bosch’s global manufacturing and sales network covers some 150 countries. The basis for the company’s future growth is its innovative strength. Bosch employs 55,800 associates in research and development at 118 locations across the globe. The Bosch Group’s strategic objective is to deliver innovations for a connected life. Bosch improves quality of life worldwide with products and services that are innovative and spark enthusiasm. In short, Bosch creates technology that is “Invented for life.”

Further information is available online at and,

PI7711 - April 19, 2012

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