Packaging Technology

Interpack 2014 Market launch: new filling and closing machine FXS Combi from Bosch Flexible solution for syringes, vials and cartridges in combination

  • Filling and closing of pre-sterilized nested syringes, vials and cartridges
  • Integrated capping station saves space and ensures maximum pharmaceutical safety
  • Flexible integration into fully automated line concepts
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  • May 08, 2014
  • Packaging Technology
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press release

Duesseldorf, Germany – At Interpack 2014, Bosch Packaging Technology, a leading supplier of process and packaging technology, presents the new filling and closing machine FXS Combi for the first time. Depending on output and container, the machine with two or five positions processes pre-sterilized nested syringes, vials and cartridges. The FXS Combi is the first filling and closing machine of this kind with an integrated capping station for vials and cartridges. It can be easily integrated into line concepts, allowing for significant space savings. The FXS Combi is suited for low and medium output rates.

Flexibility for various packaging types
The FXS Combi is an advancement of the proven FXS platform and features flexible and quickly exchangeable format parts for diverse packaging types. “To fulfil our customer’s demands for higher flexibility, a more compact footprint and extended fields of application, we transferred the successful FXS concept to further, pre-sterilized packaging types,” Klaus Ullherr, product manager at Bosch Packaging Technology explained.

“During the development of the FXS Combi, we benefitted from our many years of experience in the safe and reliable processing of syringes, vials and cartridges,” Ullherr said. The FXS Combi is the first filling and closing machine of this kind with an integrated capping station. In the consistent monobloc solution, the capping of vials and cartridges takes place directly after the stopper insertion. This ensures highest pharmaceutical safety, as the container is immediately and safely closed after filling.

Integration into fully automated line concepts
The FXS Combi operates with a combi filling station with up to six dosing heads. This makes the machine suitable for all common filling technologies, such as peristaltic or rotary slide valve piston pumps as well as the single-use filling technology PreVAS. A combination with different barrier systems is also possible; the FXS Combi is suited for both Restricted Access Barrier Systems (RABS) and isolators. By combining the new filling and closing machine with the proven upstream ATO tub opener and ABO bag opener from Bosch, it can be integrated into fully automated line concepts.

The filling and closing machine is also suited for processing vials for lyophilization, which ensures a longer life span of the pharmaceuticals. Especially high-priced pharmaceutical products and packaging types require a high product yield. Filling on a checkweigher during the start-up and run-empty process makes almost 100 percent of the pharmaceutical liquids usable for filling. Filling weights are checked via statistical in-process control (IPC). “Together with our single-use filling system PreVAS, the FXS Combi contributes to a more efficient and faster development of new medications, for instance for the treatment of cancer,” Ullherr said.

Bosch's technologies are on display at Interpack 2014, Duesseldorf, Germany from May 8 to 14 in hall 6, booth A31 – C58.

Klaus Ullherr: phone: +49 7951 402-517

Based in Waiblingen near Stuttgart, Germany, and employing 6,200 associates, the Bosch Packaging Technology division is one of the leading suppliers of process and packaging technology. At over 30 locations in more than 15 countries worldwide, a highly-qualified workforce develops and produces complete solutions for the pharmaceuticals, food, and confectionery industries. These solutions are complemented by a comprehensive after-sales service portfolio. A global service and sales network provides customers with local points of contact.

Additional information is available online at

The Bosch Group is a leading global supplier of technology and services. It employs roughly 375,000 associates worldwide (as of December 31, 2015). The company generated sales of 70.6 billion euros in 2015. Its operations are divided into four business sectors: Mobility Solutions, Industrial Technology, Consumer Goods, and Energy and Building Technology. The Bosch Group comprises Robert Bosch GmbH and its roughly 440 subsidiaries and regional companies in some 60 countries. Including sales and service partners, Bosch’s global manufacturing and sales network covers some 150 countries. The basis for the company’s future growth is its innovative strength. Bosch employs 55,800 associates in research and development at 118 locations across the globe. The Bosch Group’s strategic objective is to deliver innovations for a connected life. Bosch improves quality of life worldwide with products and services that are innovative and spark enthusiasm. In short, Bosch creates technology that is “Invented for life.”

Further information is available online at and,

PI8546 - May 08, 2014

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