Packaging Technology

Bosch CIP/SIP system for best quality cleaning Individual configuration thanks to modular design

  • Fully automatic, reproducible cleaning and sterilization
  • High cleaning quality even with short cycles
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  • October 16, 2012
  • Packaging Technology
  • Press releases

press release

The standardized compact system from Bosch Packaging Technology for cleaning and sterilization in place (CIP/SIP) is suited for pharmaceutical containers and vessels, as well as small production accessories, including filter units, mills, pumps and hoses. The modular system is manufactured in Dresden by Pharmatec, a subsidiary of Bosch Packaging Technology.

CIP/SIP systems are used for reliable and reproducible cleaning and sterilization of machinery and equipment. This cleaning and sterilization process is especially important to ensure highest product quality for sterile pharmaceuticals. The modular construction of this innovative system is designed to meet virtually all customer requirements quickly and easily. The basic configuration includes a CIP tank to mix the necessary cleaning media, a flow pump, lines for PW (purified water), WFI (water for injection), clean steam, compressed air, and the required measurement, control and valve systems.

Modular design for customer-specific configurations
The system can be quickly and easily configured with add-on modules to meet different customer specifications. In addition to a self-priming return pump, a pharmaceutical-compatible heat exchanger can be integrated into the existing CIP frame. The temperature of the cleaning media is controlled via steam or electric heat exchangers. Various dosing stations for detergent concentrates and sterile air filter units used for blowing out and drying the system can be integrated.

“The modular design and the use of proven standard components enable a fast system configuration,” explained Volker Kempf, Project Manager at Pharmatec. “This ensures efficient project execution in the shortest possible time – even when there are additional requirements.” The Dresden plant maintains a supply of all media required in the pharmaceutical industry, including WFI and pure steam, for system pre-testing. Along with installation qualification (IQ), the system also enables the implementation of the operational qualification (OQ), including spray pattern control, riboflavin testing and temperature mapping (cold spot analysis). This ensures that the CIP system goes into operation very shortly after being delivered to the customer's site.

Perfectly matched parameters
Cleaning efficiency is regulated by changing specific parameters. Time, temperature, concentration of the cleaning solutions and flow rate must be perfectly matched to achieve optimum results. The Pharmatec CIP system operates at temperatures up to 90 degrees Celsius with a flow rate ranging from 500 to 5,000 liters per hour. Process steps running in parallel ensure maximum cleaning quality with short cycles.

Volker Kempf,
phone: +49 351 28278-617

Based in Waiblingen near Stuttgart, Germany, and employing 6,200 associates, the Bosch Packaging Technology division is one of the leading suppliers of process and packaging technology. At over 30 locations in more than 15 countries worldwide, a highly-qualified workforce develops and produces complete solutions for the pharmaceuticals, food, and confectionery industries. These solutions are complemented by a comprehensive after-sales service portfolio. A global service and sales network provides customers with local points of contact.

Additional information is available online at

The Bosch Group is a leading global supplier of technology and services. It employs roughly 375,000 associates worldwide (as of December 31, 2015). The company generated sales of 70.6 billion euros in 2015. Its operations are divided into four business sectors: Mobility Solutions, Industrial Technology, Consumer Goods, and Energy and Building Technology. The Bosch Group comprises Robert Bosch GmbH and its roughly 440 subsidiaries and regional companies in some 60 countries. Including sales and service partners, Bosch’s global manufacturing and sales network covers some 150 countries. The basis for the company’s future growth is its innovative strength. Bosch employs 55,800 associates in research and development at 118 locations across the globe. The Bosch Group’s strategic objective is to deliver innovations for a connected life. Bosch improves quality of life worldwide with products and services that are innovative and spark enthusiasm. In short, Bosch creates technology that is “Invented for life.”

Further information is available online at and,

PI7767 - October 16, 2012

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